NGF processing
نویسندگان
چکیده
منابع مشابه
Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants.
NGF binds to and activates the protein tyrosine kinase gp 140prototrk. Expression of this receptor is required for at least some responses to NGF. Three outstanding issues are addressed in the present work. First, we determined whether expression of gp 140prototrk is required for all neuronal NGF responses. Second, we examined the role of gp 140prototrk in NGF binding and internalization. Third...
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Received 1 December 2013, accepted 20 December 2013. Correspondence: Dr Viviana Triaca, Institute of Biology and Cellular Neuroscience, National Research Council (CNR), European Brain Research Institute (EBRI) Rita Levi-Montalcini Foundation, Via del Fosso di Fiorano 64/65, 00143 Rome, Italy. Tel.: ++39 06 50170 3268, E-mail: viviana.triaca@ibcn.cnr.it Abstract The therapeutic focus of the scie...
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Dysfunction of nerve growth factor (NGF) and its high-affinity Tropomyosin receptor kinase A (TrkA) receptor has been suggested to contribute to the selective degeneration of basal forebrain cholinergic neurons (BFCN) associated with the progressive cognitive decline in Alzheimer's disease (AD). The aim of this review is to describe our progress in elucidating the molecular mechanisms underlyin...
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Nerve Growth Factor (NGF) was initially studied for its role as a key player in the regulation of peripheral innervations. However, the successive finding of its release in the bloodstream of male mice following aggressive encounters and its presence in the central nervous system led to the hypothesis that variations in brain NGF levels, caused by psychosocial stressor, and the related alterati...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2007
ISSN: 1934-1792
DOI: 10.3180/react_11062.2